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KMID : 1147720220150010043
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Journal of Acupuncture and Meridian Studies
2022 Volume.15 No. 1 p.43 ~ p.49
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GB20 Pharmacopuncture As a Potential Method for Brain Drug Delivery via the Perivascular Spaces
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Semyachkina-Glushkovskaya Oxana
Blokhina Inna
Navolokin Nikita
Evsukova Arina
Karandin Georgy
Khorovodov Alexander
Terskov Andrey
Fedosov Ivan
Dubrovsky Alexander
Tzoy Maria
Ageev Vasily
Agranovich Ilana
Telnova Valeria
Tsven Anna
Kurths Jurgen
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Abstract
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Background: The development of new methods of drug brain delivery is a crucial step for the effective therapy of the brain diseases. Pharma- and acupuncture are the forms of alternative therapy of the brain pathology, including an increase in the permeability of blood-brain barrier. However, the mechanisms of pharma- and acupuncture-mediated effects on the brain physiology remain not fully understood.
Results: This pilot study on healthy mice clearly demonstrates the Evans Blue spreading in the mouse head and in the brain via the perivascular spaces (PVSs) of the trigeminal structure and the cribriform plate after the dye injection into the Feng Chi point (Galbladder 20, GB20).
Conclusion: These results suggest that pharmacopuncture at GB20 can be a perspective method for brain drug delivery via PVSs.
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KEYWORD
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Pharmacopuncture, The Feng Chi point, Perivascular spaces, Delivery into the brain
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